Blood Clotting and Coagulation Factors: The Work of Yale Nemerson

Tremoli and Yale Nemerson

This study was undertaken to characterize tissue factor (TF) induction, localization, and functional activity in cultured human umbilical vein endothelial cells (HUVECs) exposed to recombinant vascular endothelial growth factor (rVEGF) and recombinant tumor necrosis factor-a (rTNF-a). rVEGF (1 nmol/L) and rTNF-a (500 U/mL) synergistically increased TF mRNA, protein, and total activity, as measu...

Theories of blood coagulation. Properties and interactions of blood clotting factors.

Two main schools of thought dominate the scene of blood coagulation and hemo­ stasis today. Both have their roots in the classic theory of blood coagulation (figure 1) described by Paul Morawitz in 1904.20 In the primitive physiological and bio­ chemical background of that period the formation of a blood clot was envisioned correctly as the result of the conversion of prothrombin to thrombin by...

Nomenclature for blood clotting factors.

Influence of the Physiological Blood Clotting Process on the Coagulation of Blood by Staphylocoagulase

The conversion of plasma to serum results in a variable loss of the coagulase-reacting factor (C.R.F.) of the plasma. The C.R.F. loss is incurred during the process of prothrombin conversion: conditions which favor the most effective prothrombin conversion result in maximal C.R.F. loss, while factors which interfere with prothrombin conversion spare the C.R.F. In a system containing an adequate...

Blood clotting factors in cerebrospinal fluid.

The activity of blood clotting factors has been investigated in cerebrospinal fluid. No cephalin-like activity was found in cerebrospinal fluid but prothrombin activity averaged about 0.5% of normal plasma activity. The activity of factor VII was negligible in almost all cases. The activity of antihaemophilic factors showed great variation but in the majority of cases it did not exceed 1% of no...